I'm Hersh, a scientist with a background in quantitative biology and computer science.
I apply computational and synthetic biology to reprogram human cells to create living therapies for cancer and other complex diseases.
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Published in Science
Allen GM*, Frankel NW*, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA.
We built a synthetic circuit that wires tumor antigen detection to cytokine production in T cells. This circuit produces the inflammatory cytokine IL-2 at super-physiological levels, and enables engineered T cells to overcome imunosuppressive “cold” tumor microenvironments, which are a hallmark of the cancers with the most severe prognoses.
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Published in Clinical Cancer Research
Bhargava HK, Leo P, Elliott R, Janowcyzk A, Whitney J, Gupta S, Fu P, Yamoah K, Rebbeck T, Feldman D, Lal P, Madabhushi A
We developed computer vision and machine learning to predict prostate cancer recurrence risk based on quantitative measurements of the intratumoral stroma computed from digitized H&E images.