Scientific Paper

Synthetic cytokine circuits that drive T cells into immune-excluded tumors.

Published in Science

Allen GM*, Frankel NW*, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA.

We built a synthetic circuit that wires tumor antigen detection to cytokine production in T cells. This circuit produces the inflammatory cytokine IL-2 at super-physiological levels, and enables engineered T cells to overcome imunosuppressive “cold” tumor microenvironments, which are a hallmark of the cancers with the most severe prognoses.

Media & Press

• Cell Design Institute Explanatory Video (YouTube)

• Killing Pancreatic Cancer with T Cells that Supercharge Themselves (UCSF News)

• Perspective: Engineering time-controlled immunotherapy (Science)

• Cancer treatments boosted by immune-cell hacking (Nature News)

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Scientific Paper

Computationally derived image signature of stromal morphology is prognostic of prostate cancer recurrence following prostatectomy in African American patients.

Published in Clinical Cancer Research

Bhargava HK, Leo P, Elliott R, Janowcyzk A, Whitney J, Gupta S, Fu P, Yamoah K, Rebbeck T, Feldman D, Lal P, Madabhushi A

We developed computer vision and machine learning to predict prostate cancer recurrence risk based on quantitative measurements of the intratumoral stroma computed from digitized H&E images.

Media & Press

• Press Release (AAAS EurekAlert)

• Health IT Analytics

• CWRU The Daily

• Towards Data Science Article

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