I'm Hersh, a scientist with a background in quantitative biology and computer science.
I apply computational and synthetic biology to reprogram human cells to create living therapies for cancer and other complex diseases.
I'm also a co-founder of Skolay and H2 Micro.
Check out my scientific work, writing, and other projects.
Or, scroll to see some highlights.
Published in Science
Allen GM*, Frankel NW*, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA.
We built a synthetic circuit that wires tumor antigen detection to cytokine production in T cells. This circuit produces the inflammatory cytokine IL-2 at super-physiological levels, and enables engineered T cells to overcome imunosuppressive “cold” tumor microenvironments, which are a hallmark of the cancers with the most severe prognoses.
Killing Pancreatic Cancer with T Cells that Supercharge Themselves (UCSF News)
Perspective: Engineering time-controlled immunotherapy (Science)
Cancer treatments boosted by immune-cell hacking (Nature News)
Skolay helps thoughtful people with an audience (like authors, podcasters, Substackers, journalists) have casual 1:1 office-hours-like conversations without the need to give out personal info, send emails, reconcile schedules, or independently solicit payment.Skolay Website
Published in Clinical Cancer Research
Bhargava HK, Leo P, Elliott R, Janowcyzk A, Whitney J, Gupta S, Fu P, Yamoah K, Rebbeck T, Feldman D, Lal P, Madabhushi A
We developed computer vision and machine learning to predict prostate cancer recurrence risk based on quantitative measurements of the intratumoral stroma computed from digitized H&E images.
Email me at hello [at] hershbhargava.com