I'm Hersh, a student and scientist with a background in biology and computer science.
I am interested in fusing computational and synthetic biology to advance the field of cell design, in particular for the development of cellular therapies.
2020 | Proceedings of the National Academy of Science | Bhargava H.K., Tabata K., Byck J.M., Hamasaki M., Farrell D.P., Anishchenko I., DiMaio F., Im Y.J., Yoshimori T., Hurley J.H.
We report the novel atomic structure of autophagy inhibitor Rubicon bound to GTPase Rab7. Our work provides a roadmap to block Rubicon localization and activity in order to upregulate autophagy, a major drug development goal.PDF Journal Website PDB Entry
2020 | Clinical Cancer Research | Bhargava H.K., Leo, P., Elliott, R., Janowcyzk, A., Whitney, J., Gupta, S., Fu, P., Yamoah, K., Rebbeck, T., Feldman, D., Lal, P., Madabhushi, A.
We developed computer vision and machine learning to predict prostate cancer recurrence risk based on quantitative measurements of the intratumoral stroma computed from digitized H&E images.PDF Journal Website
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I am fascinated by biological systems, from molecular physics to human behavior. My goal is to shine light on how life works from the ground up, and in doing so contribute to the improvement of the human condition. I am pursuing this goal through a career in life science research, augmented with computational techniques.
Currently, I am acquiring the skills to effectively tackle questions in life science. I have been part of several different labs, working with techniques ranging from x-ray crystallography to deep learning. In addition, I co-founded the software development and consulting company H2 Micro. In 2019, I graduated from Berkeley with a degree in Molecular and Cell Biology, and am now pursuing a Ph.D. in Biophysics at UCSF.
I was born and raised in Maine, and enjoy playing the violin, rock climbing, and drinking coffee. I graduated in 2015 from the New Hampshire boarding school Phillips Exeter Academy, where I focused on classical languages and molecular biology.
I am always happy to chat about interesting thoughts, ideas, or opportunities.
Feel free to reach out at email@example.com!